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KMID : 0380020090240020122
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Korean Journal of Biotechnology and Bioengineering
2009 Volume.24 No. 2 p.122 ~ p.130
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Selection and Mechanism of Anti-Obesity Agents from Natural Products Based on Anti-Angiogenesis
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Shin Jin-Hyuk
Lee Jin-Hee
Kang Kyeong-Wan
Hwang Jae-Ho
Han Kyeong-Ho
Shin Tai-Sun
Kim Min-Yong
Kim Jong-Deog
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Abstract
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Anti-angiogenic mechanism was examined for anti-obesity agents with the extract of P.radix, P.semen, S.hebra and C.furctus through anti-cell adhesion effect and western blot. Cell adhesion molecules, VCAM-1 was supressed with the order of P.radix (0.2 ppm, 125%) > P.semen (0.5 ppm, 100%) > S.hebra (5.0 ppm, 114%) > C. furctus (5.0 ppm, 111.8%), ICAM-1 was inhibited by P.radix (0.25 ppm, 130%) > P.semen (0.5 ppm, 100%) > S.hebra (5.0 ppm, 138%) > C. furctus (5.0 ppm, 66.7%), E-Selectin was also supressed P.radix (0.25 ppm, 100%) > P.semen (1.0 ppm, 128%) > S.hebra (5.0 ppm, 120%) > C. furctus (5.0 ppm, 100.7%). And signal molecules, VE-cadherin was supressed by P.radix and S.hebra, -catenin was inhibited by P.radix, and Akt was supressed all these 4 kinds of natural products. These P.radix, P.semen, S.hebra and C.furctus were showed the possibility of anti-obesity agents based on anti-angiogenesis.
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KEYWORD
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Anti-angiogenesis, anti-obesity, cell adhesion molecule, signal molecule, natural products
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